Mechanism of action and therapeutic use of bempedoic acid in atherosclerosis and metabolic syndrome

Mechanism of action and therapeutic use of bempedoic acid in atherosclerosis and metabolic syndrome

Bempedoic acid is a new cholesterol-lowering drug, which has recently received US FDA and EMA approval. This drug targets lipid and glucose metabolism as well as inflammation via downregulation of ATP-citrate lyase and upregulation of AMP-activated protein kinase (AMPK). The primary effect is the re...

Full description

Bibliographic Details
Main Authors: Gianni Biolo, Pierandrea Vinci, Alessandro Mangogna, Matteo Landolfo, Paolo Schincariol, Nicola Fiotti, Filippo Mearelli, Filippo Giorgio Di Girolamo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
bempedoic acid
atherosclerosis
cholesterol
statins
ezetimibe
PCSK9 inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.1028355/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.1028355/full

Similar Items