DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers

DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers

CAR-T (chimeric antigen receptor T cells) immunotherapy is effective in many hematological cancers; however, efficacy in solid tumors is disappointing. Doublecortin-like kinase 1 (DCLK1) labels tumor stem cells (TSCs) in genetic mouse models of colorectal cancer (CRC). Here, we describe a novel CAR-...

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Bibliographic Details
Main Authors: Sripathi M. Sureban, Robert Berahovich, Hua Zhou, Shirley Xu, Lijun Wu, Kai Ding, Randal May, Dongfeng Qu, Edwin Bannerman-Menson, Vita Golubovskaya, Courtney W. Houchen
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cancers
Subjects:
dclk1
car-t
tumor stem cells
immunotherapy
clonogenicity
Online Access:https://www.mdpi.com/2072-6694/12/1/54

Internet

https://www.mdpi.com/2072-6694/12/1/54

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