Extraction of niclosamide from commercial approved tablets into aqueous buffered solution creates potentially approvable oral and nasal sprays against COVID-19 and other respiratory infections
Abstract Motivation The low solubility, weak acid drug, niclosamide is a host cell modulator with broad-spectrum anti-viral cell-activity against many viruses, including stopping the SARS-CoV-2 virus from infecting cells in cell culture. As a result, a simple universal nasal spray preventative was p...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-04-01
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| Series: | AAPS Open |
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| Online Access: | https://doi.org/10.1186/s41120-023-00072-x |