Extraction of niclosamide from commercial approved tablets into aqueous buffered solution creates potentially approvable oral and nasal sprays against COVID-19 and other respiratory infections

Extraction of niclosamide from commercial approved tablets into aqueous buffered solution creates potentially approvable oral and nasal sprays against COVID-19 and other respiratory infections

Abstract Motivation The low solubility, weak acid drug, niclosamide is a host cell modulator with broad-spectrum anti-viral cell-activity against many viruses, including stopping the SARS-CoV-2 virus from infecting cells in cell culture. As a result, a simple universal nasal spray preventative was p...

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Bibliographic Details
Main Author: David Needham
Format: Article
Language:English
Published: SpringerOpen 2023-04-01
Series:AAPS Open
Subjects:
Niclosamide
Dissolution
Yomesan
Luxiaoliunpian
Niclosig
pH buffer
Online Access:https://doi.org/10.1186/s41120-023-00072-x

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