ISG15 protects human Tregs from interferon alpha‐induced contraction in a cell‐intrinsic fashion

ISG15 protects human Tregs from interferon alpha‐induced contraction in a cell‐intrinsic fashion

Abstract Objectives Type I interferons (IFNs) inhibit regulatory T‐cell (Treg) expansion and activation, making them beneficial in antiviral responses, but detrimental in autoimmune diseases. Herein, we investigate the role of ISG15 in human Tregs in the context of refractoriness to type I IFN stimu...

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Bibliographic Details
Main Authors: Ilenia Pacella, Francesca Romana Spinelli, Martina Severa, Eleonora Timperi, Gloria Tucci, Marta Zagaglioni, Fulvia Ceccarelli, Fabiana Rizzo, Eliana M Coccia, Roosheel S Patel, Marta Martin‐Fernandez, Dusan Bogunovic, Fabrizio Conti, Vincenzo Barnaba, Silvia Piconese
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
hepatitis C
interferon
ISG15
lupus
STAT1
Tregs
Online Access:https://doi.org/10.1002/cti2.1221

Internet

https://doi.org/10.1002/cti2.1221

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