APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease

Abstract Background Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer’s disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein E (APOE) ε4 genotype plays a major role. We aimed to identify the mo...

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Détails bibliographiques
Auteurs principaux: Elles Konijnenberg, Betty M. Tijms, Johan Gobom, Valerija Dobricic, Isabelle Bos, Stephanie Vos, Magda Tsolaki, Frans Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, Lutz Frölich, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Charlotte E. Teunissen, Robert Veerhuis, August B. Smit, Philip Scheltens, Henrik Zetterberg, Pieter Jelle Visser
Format: Article
Langue:English
Publié: BMC 2020-05-01
Collection:Alzheimer’s Research & Therapy
Sujets:
Amyloid aggregation
APOE genotype
CSF proteomics
Accès en ligne:http://link.springer.com/article/10.1186/s13195-020-00628-z

Internet

http://link.springer.com/article/10.1186/s13195-020-00628-z

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