Synthesis of phthalazine-based derivatives as selective anti-breast cancer agents through EGFR-mediated apoptosis: in vitro and in silico studies

Synthesis of phthalazine-based derivatives as selective anti-breast cancer agents through EGFR-mediated apoptosis: in vitro and in silico studies

Abstract The parent 2-(4-benzyl-1-oxophthalazin-2(1H)-yl)-acetohydrazide (4) has twenty-nine compounds. The starting material for their corresponding mono, dipeptides and reactions with active methylene compounds were produced by chemoselective N-alkylation of 4-Benzyl-2H-phthalazin-1-one (2) with e...

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Bibliographic Details
Main Authors: Sara M. Emam, Samir M. El Rayes, Ibrahim A. I. Ali, Hamdy A. Soliman, Mohamed S. Nafie
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Chemistry
Subjects:
Phthalazine-based
Selective anti-breast
EGFR-mediated
Apoptosis
Online Access:https://doi.org/10.1186/s13065-023-00995-2

Internet

https://doi.org/10.1186/s13065-023-00995-2

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