Activation of Steroidogenesis, Anti-Apoptotic Activity, and Proliferation in Porcine Granulosa Cells by <i>RUNX1</i> Is Negatively Regulated by H3K27me3 Transcriptional Repression

Activation of Steroidogenesis, Anti-Apoptotic Activity, and Proliferation in Porcine Granulosa Cells by <i>RUNX1</i> Is Negatively Regulated by H3K27me3 Transcriptional Repression

H3K27me3 is an epigenetic modification that results in the repression of gene transcription. The transcription factor RUNX1 (the runt-related transcription factor 1) influences granulosa cells’ growth and ovulation. This research uses ELISA, flow cytometry, EDU, ChIP-PCR, WB and qPCR to investigate...

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Bibliographic Details
Main Authors: Yuyi Zhong, Liying Li, Yingting He, Bo He, Zhonghui Li, Zhe Zhang, Hao Zhang, Xiaolong Yuan, Jiaqi Li
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Genes
Subjects:
H3K27me3
<i>RUNX1</i>
granulosa cells
steroidogenesis
cell apoptosis and proliferation
antral follicles
Online Access:https://www.mdpi.com/2073-4425/11/5/495

Internet

https://www.mdpi.com/2073-4425/11/5/495

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