Extracellular Vesicles from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients Deliver MiR-21 and Induce Methotrexate Resistance in Lung Cancer Cells

Extracellular Vesicles from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients Deliver MiR-21 and Induce Methotrexate Resistance in Lung Cancer Cells

Leptomeningeal metastasis (LM) is a common and fatal complication of advanced non-small cell lung cancer (NSCLC) caused by the spread of malignant cells to the leptomeninges and cerebrospinal fluid (CSF). While intra-CSF methotrexate (MTX) chemotherapy can improve prognosis, eventual MTX resistance...

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Bibliographic Details
Main Authors: Ji Hye Im, Kyue-Yim Lee, Yoona Seo, Jiho Rhim, Yun-Sik Dho, Byong Chul Yoo, Jong Bae Park, Sang Hoon Shin, Heon Yoo, Jong Heon Kim, Ho-Shin Gwak
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
leptomeningeal metastasis
cerebrospinal fluid
methotrexate
extracellular vesicle
miR-21
Online Access:https://www.mdpi.com/1422-0067/25/6/3124

Internet

https://www.mdpi.com/1422-0067/25/6/3124

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