Intermittent high glucose-induced oxidative stress modulates retinal pigmented epithelial cell autophagy and promotes cell survival via increased HMGB1

Intermittent high glucose-induced oxidative stress modulates retinal pigmented epithelial cell autophagy and promotes cell survival via increased HMGB1

Abstract Background In this study, we evaluated the effects of intermittent high glucose on oxidative stress production in retinal pigmented epithelial (RPE) cells and explored whether the mechanisms of autophagy and apoptosis in oxidative stress are associated with high-mobility group box 1 (HMGB1)...

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Bibliographic Details
Main Authors: Wei Zhang, Jian Song, Yue Zhang, Yingxue Ma, Jing Yang, Guanghui He, Song Chen
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Ophthalmology
Subjects:
Intermittent high glucose
HMGB1
Oxidative stress
Autophagy
Retinal pigment epithelium cell
Online Access:http://link.springer.com/article/10.1186/s12886-018-0864-5

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http://link.springer.com/article/10.1186/s12886-018-0864-5

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