Maintaining Genome Integrity: Protein Kinases and Phosphatases Orchestrate the Balancing Act of DNA Double-Strand Breaks Repair in Cancer

Maintaining Genome Integrity: Protein Kinases and Phosphatases Orchestrate the Balancing Act of DNA Double-Strand Breaks Repair in Cancer

DNA double-strand breaks (DSBs) are the most lethal DNA damages which lead to severe genome instability. Phosphorylation is one of the most important protein post-translation modifications involved in DSBs repair regulation. Kinases and phosphatases play coordinating roles in DSB repair by phosphory...

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Bibliographic Details
Main Authors: Sisi Qin, Ichiwa Kitty, Yalan Hao, Fei Zhao, Wootae Kim
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
DNA damage
cancer therapeutics
kinase
phosphatase
Online Access:https://www.mdpi.com/1422-0067/24/12/10212

Internet

https://www.mdpi.com/1422-0067/24/12/10212

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