Selective optogenetic control of Gq signaling using human Neuropsin

Selective optogenetic control of Gq signaling using human Neuropsin

Gq proteins are one of four major classes of G proteins; optogenetic receptors for selective and repetitive activation of Gq proteins with fast kinetics are lacking. Here the authors report UV light-dependent Gq signalling using human Neuropsin (hOPN5) and demonstrate its potential as an optogenetic...

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Bibliographic Details
Main Authors: Ahmed Wagdi, Daniela Malan, Udhayabhaskar Sathyanarayanan, Janosch S. Beauchamp, Markus Vogt, David Zipf, Thomas Beiert, Berivan Mansuroglu, Vanessa Dusend, Mark Meininghaus, Linn Schneider, Bernd Kalthof, J. Simon Wiegert, Gabriele M. König, Evi Kostenis, Robert Patejdl, Philipp Sasse, Tobias Bruegmann
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29265-w

Internet

https://doi.org/10.1038/s41467-022-29265-w

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