Leukemogenic SHP2 mutations lead to erythropoietin independency of HCD-57 cells: a novel model for preclinical research of SHP2-mutant JMML

Leukemogenic SHP2 mutations lead to erythropoietin independency of HCD-57 cells: a novel model for preclinical research of SHP2-mutant JMML

Abstract Leukemogenic SHP2 mutations occur in 35% of patients with juvenile myelomonocytic leukemia (JMML), a rare but fatal hematopoietic malignancy without representative cell models, which are urgently needed to investigate the pathogenesis and to develop novel therapeutic strategies. In this stu...

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Bibliographic Details
Main Authors: Yuming Zhao, Chunxiao He, Dengyang Zhang, Yao Guo, Zhiyong Peng, Liuting Yu, Na Li, Chun Chen, Zhizhuang Joe Zhao, Yun Chen
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Experimental Hematology & Oncology
Subjects:
SHP2
Cell model
JMML
HCD-57
Online Access:https://doi.org/10.1186/s40164-023-00379-1

Internet

https://doi.org/10.1186/s40164-023-00379-1

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