Conditional knockout of ASK1 in microglia/macrophages attenuates epileptic seizures and long-term neurobehavioural comorbidities by modulating the inflammatory responses of microglia/macrophages

Conditional knockout of ASK1 in microglia/macrophages attenuates epileptic seizures and long-term neurobehavioural comorbidities by modulating the inflammatory responses of microglia/macrophages

Abstract Background Apoptosis signal-regulating kinase 1 (ASK1) not only causes neuronal programmed cell death via the mitochondrial pathway but also is an essential component of the signalling cascade during microglial activation. We hypothesize that ASK1 selective deletion modulates inflammatory r...

Full description

Bibliographic Details
Main Authors: Yiying Zhang, Zhangyang Wang, Rongrong Wang, Lu Xia, Yiying Cai, Fangchao Tong, Yanqin Gao, Jing Ding, Xin Wang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Neuroinflammation
Subjects:
ASK1
Epilepsy
Neurobehaviors
Neuroinflammation
Microglial/macrophage heterogeneity
Online Access:https://doi.org/10.1186/s12974-022-02560-5

Internet

https://doi.org/10.1186/s12974-022-02560-5

Similar Items