Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype

Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype

Background: Subject C135 is one of the members of the Sydney Blood Bank Cohort, infected in 1981 through transfusion with attenuated nef/3′ long terminal repeat (LTR)-deleted HIV-1, and has maintained undetectable plasma viral load and steady CD4 cell count, in the absence of therapy. Uniquely, C135...

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Bibliographic Details
Main Authors: John Zaunders, Wayne B. Dyer, Melissa Churchill, C Mee Ling Munier, Philip H. Cunningham, Kazuo Suzuki, Kristin McBride, Will Hey-Nguyen, Kersten Koelsch, Bin Wang, Bonnie Hiener, Sarah Palmer, Paul R. Gorry, Michelle Bailey, Yin Xu, Mark Danta, Nabila Seddiki, David A. Cooper, Nitin K. Saksena, John S. Sullivan, Sean Riminton, Jenny Learmont, Anthony D. Kelleher
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Journal of Virus Eradication
Subjects:
HIV-1
CD4
CCR5
Nef
Online Access:http://www.sciencedirect.com/science/article/pii/S205566402030056X

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http://www.sciencedirect.com/science/article/pii/S205566402030056X

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