Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked <i>Bis</i>-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K

Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked <i>Bis</i>-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K

A series of new 1,2,4-triazolo-linked <i>bis</i>-indolyl conjugates (<b>15a–r</b>) were prepared by multistep synthesis and evaluated for their cytotoxic activity against various human cancer cell lines. It was observed that they were more susceptible to colon and breast canc...

Full description

Bibliographic Details
Main Authors: Prasanna A. Yakkala, Samir R. Panda, Syed Shafi, V. G. M. Naidu, M. Shahar Yar, Philemon N. Ubanako, Samson A. Adeyemi, Pradeep Kumar, Yahya E. Choonara, Eugene V. Radchenko, Vladimir A. Palyulin, Ahmed Kamal
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
1,2,4-triazolo <i>bis</i>-indolyl conjugates
cytotoxicity
colon cancer
β-catenin pathway
PI3K/tankyrase inhibitors
Online Access:https://www.mdpi.com/1420-3049/27/21/7642

Internet

https://www.mdpi.com/1420-3049/27/21/7642

Similar Items