Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures

Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures

Abstract Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular and multi-parametric magnetic resonance imaging (M...

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Main Authors: Leland S. Hu, Fulvio D’Angelo, Taylor M. Weiskittel, Francesca P. Caruso, Shannon P. Fortin Ensign, Mylan R. Blomquist, Matthew J. Flick, Lujia Wang, Christopher P. Sereduk, Kevin Meng-Lin, Gustavo De Leon, Ashley Nespodzany, Javier C. Urcuyo, Ashlyn C Gonzales, Lee Curtin, Erika M. Lewis, Kyle W. Singleton, Timothy Dondlinger, Aliya Anil, Natenael B. Semmineh, Teresa Noviello, Reyna A. Patel, Panwen Wang, Junwen Wang, Jennifer M. Eschbacher, Andrea Hawkins-Daarud, Pamela R. Jackson, Itamar S. Grunfeld, Christian Elrod, Gina L. Mazza, Sam C. McGee, Lisa Paulson, Kamala Clark-Swanson, Yvette Lassiter-Morris, Kris A. Smith, Peter Nakaji, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Devi P. Patra, Naresh P. Patel, Mark Lyons, Matthew Neal, Kliment Donev, Maciej M. Mrugala, Alyx B. Porter, Scott C. Beeman, Todd R. Jensen, Kathleen M. Schmainda, Yuxiang Zhou, Leslie C. Baxter, Christopher L. Plaisier, Jing Li, Hu Li, Anna Lasorella, C. Chad Quarles, Kristin R. Swanson, Michele Ceccarelli, Antonio Iavarone, Nhan L. Tran
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41559-1

Internet

https://doi.org/10.1038/s41467-023-41559-1

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