Time-resolved role of P2X4 and P2X7 during CD8+ T cell activation

Time-resolved role of P2X4 and P2X7 during CD8+ T cell activation

CD8+ T cells are a crucial part of the adaptive immune system, responsible for combating intracellular pathogens and tumor cells. The initial activation of T cells involves the formation of highly dynamic Ca2+ microdomains. Recently, purinergic signaling was shown to be involved in the formation of...

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Bibliographic Details
Main Authors: Valerie J. Brock, Niels Christian Lory, Franziska Möckl, Melina Birus, Tobias Stähler, Lena-Marie Woelk, Michelle Jaeckstein, Joerg Heeren, Friedrich Koch-Nolte, Björn Rissiek, Hans-Willi Mittrücker, Andreas H. Guse, René Werner, Björn-Philipp Diercks
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
CD8 + T cells
Ca2+ imaging
activation
TCR stimulation
Ca2+ microdomains
NFAT
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1258119/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1258119/full

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