Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA

Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA

Abstract Objective This study aimed to evaluate the effectiveness of metformin versus placebo in overweight patients with knee osteoarthritis (OA). In addition, to assess the effects of inflammatory mediators and apoptotic proteins in the pathogenesis of OA, the genetic polymorphisms of two genes, o...

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Bibliographic Details
Main Authors: Nahid Alimoradi, Mohammad Tahami, Negar Firouzabadi, Elham Haem, Amin Ramezani
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Metformin
Bcl-2
CXCL-16
KOOS
mTOR
Online Access:https://doi.org/10.1186/s13075-023-03025-7

Internet

https://doi.org/10.1186/s13075-023-03025-7

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