Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom

Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom

DNA synthesis catalyzed by DNA polymerase is essential for all life forms, and phosphodiester bond formation with phosphorus center inversion is a key step in this process. Herein, by using a single-selenium-atom-modified dNTP probe, we report a novel strategy to visualize the reaction stereochemist...

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Bibliographic Details
Main Authors: Tong Qin, Bei Hu, Qianwei Zhao, Yali Wang, Shaoxin Wang, Danyan Luo, Jiazhen Lyu, Yiqing Chen, Jianhua Gan, Zhen Huang
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
polymerase
single selenium atom
phosphodiester bond formation
configuration inversion
metal ions
Online Access:https://www.mdpi.com/1422-0067/24/21/15758

Internet

https://www.mdpi.com/1422-0067/24/21/15758

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