Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

Summary: Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in PC12 cells. Knocking down Runx1 in dorsal root ga...

Full description

Bibliographic Details
Main Authors: Zhu-Lin Yuan, Xiao-Dan Liu, Zi-Xian Zhang, Song Li, Yue Tian, Ke Xi, Jie Cai, Xiao-Mei Yang, Min Liu, Guo-Gang Xing
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Physiology
Molecular physiology
Molecular biology
Molecular medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222012081

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222012081

Similar Items