Evidence of cerebellar TDP-43 loss of function in FTLD-TDP

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP

Abstract Frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) is a neurodegenerative disease primarily affecting the frontal and/or temporal cortices. However, a growing body of evidence suggests that the cerebellum contributes to biochemical, cognitive, and behavioral changes in FTLD-...

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Bibliographic Details
Main Authors: Sarah Pickles, Tania F. Gendron, Yuka Koike, Mei Yue, Yuping Song, Jennifer M. Kachergus, J. Shi, Michael DeTure, E. Aubrey Thompson, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, Zbigniew K. Wszolek, Keith A. Josephs, Dennis W. Dickson, Leonard Petrucelli, Casey N. Cook, Mercedes Prudencio
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Acta Neuropathologica Communications
Subjects:
Cerebellum
Frontotemporal lobar degeneration
Stathmin-2
TDP-43
Online Access:https://doi.org/10.1186/s40478-022-01408-6

Internet

https://doi.org/10.1186/s40478-022-01408-6

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