Impaired Cytotoxic CD8<sup>+</sup> T Cell Response in Elderly COVID-19 Patients

Impaired Cytotoxic CD8<sup>+</sup> T Cell Response in Elderly COVID-19 Patients

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic T cell response has not been very well characterized in COVID-19...

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Bibliographic Details
Main Authors: Jaana Westmeier, Krystallenia Paniskaki, Zehra Karaköse, Tanja Werner, Kathrin Sutter, Sebastian Dolff, Marvin Overbeck, Andreas Limmer, Jia Liu, Xin Zheng, Thorsten Brenner, Marc M. Berger, Oliver Witzke, Mirko Trilling, Mengji Lu, Dongliang Yang, Nina Babel, Timm Westhoff, Ulf Dittmer, Gennadiy Zelinskyy
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
COVID-19
SARS-CoV-2
cytotoxic T cells
CD8+
CD4+
PD-1
Online Access:https://journals.asm.org/doi/10.1128/mBio.02243-20

Internet

https://journals.asm.org/doi/10.1128/mBio.02243-20

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