Promoter hypermethylation-related reduced somatostatin production promotes uncontrolled cell proliferation in colorectal cancer.

Promoter hypermethylation-related reduced somatostatin production promotes uncontrolled cell proliferation in colorectal cancer.

<h4>Background</h4>Somatostatin (SST) has anti-proliferative and pro-apoptotic effects. Our aims were to analyze and compare the SST expression during normal aging and colorectal carcinogenesis at mRNA and protein levels. Furthermore, we tested the methylation status of SST in biopsy sam...

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Bibliographic Details
Main Authors: Katalin Leiszter, Ferenc Sipos, Orsolya Galamb, Tibor Krenács, Gábor Veres, Barna Wichmann, István Fűri, Alexandra Kalmár, Árpád V Patai, Kinga Tóth, Gábor Valcz, Zsolt Tulassay, Béla Molnár
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0118332

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https://doi.org/10.1371/journal.pone.0118332

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