X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium.

X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium.

Damage to the retinal pigment epithelium (RPE) is an early event in the pathogenesis of age-related macular degeneration (AMD). X-box binding protein 1 (XBP1) is a key transcription factor that regulates endoplasmic reticulum (ER) homeostasis and cell survival. This study aimed to delineate the role...

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Bibliographic Details
Main Authors: Yimin Zhong, Jingming Li, Joshua J Wang, Chen Chen, Julie-Thu A Tran, Anisse Saadi, Qiang Yu, Yun-zheng Le, Md Nawajes A Mandal, Robert E Anderson, Sarah X Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3371004?pdf=render

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http://europepmc.org/articles/PMC3371004?pdf=render

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