Identification of polyphenols that repair the ultraviolet-B-induced DNA damage via SIRT1-dependent XPC/XPA activation

Identification of polyphenols that repair the ultraviolet-B-induced DNA damage via SIRT1-dependent XPC/XPA activation

Ultraviolet (UV)-B is an established etiological cause of skin damage. SIRT1, a mammalian SIR2 homolog localized in the nucleus and cytosol, plays a protective role in UVB-induced DNA damage. In this study, we established a method of screening foods and food ingredients, which augment the SIRT1 prom...

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Bibliographic Details
Main Authors: Zhao Chong, Haruka Matsuo, Shiori Onoue, Hiroaki Yamamoto, Hideyuki Ito, Yoshinori Katakura
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Journal of Functional Foods
Subjects:
Pomegranate
Punicalagin
Urolithin A
SIRT1
DNA damage
XPA/XPC
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464619300179

Internet

http://www.sciencedirect.com/science/article/pii/S1756464619300179

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