The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype

The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype

Macrophages (Mφs) play a crucial role in the pathological progression of osteoarthritis (OA) by regulating inflammation and tissue repair. Decreasing pro-inflammatory M1-Mφs and increasing anti-inflammatory M2-Mφs can alleviate OA-related inflammation and promote cartilage repair. Apoptosis is a nat...

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Bibliographic Details
Main Authors: Leilei Qin, Jianye Yang, Xudong Su, Xilan li, Yiting Lei, Lili Dong, Hong Chen, Cheng Chen, Chen Zhao, Huan Zhang, Jun Deng, Ning Hu, Wei Huang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-05-01
Series:Genes and Diseases
Subjects:
Apoptotic body
Extracellular vesicles
Macrophage phenotype switch
MicroRNA-21
Osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304222002604

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http://www.sciencedirect.com/science/article/pii/S2352304222002604

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