Pregnenolone 16-Alpha Carbonitrile, an Agonist of Rodent Pregnane X Receptor, Regulates Testosterone Biosynthesis in Rodent Leydig Cells

Pregnenolone 16-Alpha Carbonitrile, an Agonist of Rodent Pregnane X Receptor, Regulates Testosterone Biosynthesis in Rodent Leydig Cells

Leydig cells (LCs) in the testes produce the male sex hormone testosterone (T). Several xenobiotics, including clinical drugs, supplements, and environmental chemicals, are known to disrupt T homeostasis. Notably, some of these xenobiotics are known to activate the pregnane X receptor (PXR), a ligan...

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Bibliographic Details
Main Authors: Julia M. Salamat, Elizabeth M. Ayala, Chen-Che J. Huang, Frank S. Wilbanks, Rachel C. Knight, Benson T. Akingbemi, Satyanarayana R. Pondugula
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Journal of Xenobiotics
Subjects:
Leydig cells
MA-10 cells
pregnenolone 16-alpha carbonitrile (PCN)
pregnane X receptor (PXR)
testis
testosterone
Online Access:https://www.mdpi.com/2039-4713/14/3/71

Internet

https://www.mdpi.com/2039-4713/14/3/71

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