A mouse model of vitiligo based on endogenous auto-reactive CD8 + T cell targeting skin melanocyte

A mouse model of vitiligo based on endogenous auto-reactive CD8 + T cell targeting skin melanocyte

Abstract Vitiligo is the most common human skin depigmenting disorder. It is mediated by endogenous autoreactive CD8 + T cells that destruct skin melanocytes. This disease has an estimated prevalence of 1% of the global population and currently has no cure. Animal models are indispensable tools for...

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Bibliographic Details
Main Authors: Daoming Chen, Zijian Xu, Jun Cui, Ting Chen
Format: Article
Language:English
Published: SpringerOpen 2022-10-01
Series:Cell Regeneration
Subjects:
Vitiligo
Mouse model
Activation
Endogenous autoreactive cytotoxic CD8 + T cells
Online Access:https://doi.org/10.1186/s13619-022-00132-9

Internet

https://doi.org/10.1186/s13619-022-00132-9

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