Temperature- and pH-responsive injectable chitosan hydrogels loaded with doxorubicin and curcumin as long-lasting release platforms for the treatment of solid tumors

Temperature- and pH-responsive injectable chitosan hydrogels loaded with doxorubicin and curcumin as long-lasting release platforms for the treatment of solid tumors

The efficacy of treating solid tumors with chemotherapy is primarily hindered by dose-limiting toxicity due to off-target effects and the heterogeneous drug distribution caused by the dense extracellular matrix. The enhanced permeability and retention (EPR) effect within tumors restricts the circula...

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Bibliographic Details
Main Authors: Na Li, Jianjun Lin, Chunping Liu, Qian Zhang, Riwang Li, Chuang Wang, Chaochao Zhao, Lu Lu, Changren Zhou, Jinhuan Tian, Shan Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hydrogel
pH-sensitive
injectable
curcumin
doxorubicin
liposome
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1043939/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.1043939/full

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