Genome Instability and Long Noncoding RNA Reveal Biomarkers for Immunotherapy and Prognosis and Novel Competing Endogenous RNA Mechanism in Colon Adenocarcinoma

Genome Instability and Long Noncoding RNA Reveal Biomarkers for Immunotherapy and Prognosis and Novel Competing Endogenous RNA Mechanism in Colon Adenocarcinoma

Background: Long noncoding RNAs (lncRNAs) crucially modulate DNA damage responses/repair in cancer cells. However, the underlying regulatory role of genome integrity and its clinical value in colon adenocarcinoma (COAD) remains unclear. This study links genome instability to lncRNA using computation...

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Bibliographic Details
Main Authors: Ziyuan Ren, Zhonglin Wang, Donghong Gu, Hanchen Ma, Yan Zhu, Menghua Cai, Jianmin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
genome instability
lncRNA
ceRNA
immune checkpoint inhibitor
MSI
tumor heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.740455/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.740455/full

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