Nestin(+) tissue-resident multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodeling

Nestin(+) tissue-resident multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodeling

Tumor vessels with resistance to anti-angiogenic therapy are characterized by the normalization of the vascular structures through integration of mature pericytes and smooth muscle cells (SMC) into the vessel wall, a process termed vessel stabilization. Unfortunately, stabilization-associated vascul...

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Bibliographic Details
Main Authors: Diana eKlein, Nicole eMeissner, Veronika eKleff, Holger eJastrow, Masahiro eYamaguchi, Süleyman eErgün, Verena eJendrossek
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Oncology
Subjects:
Pericytes
mesenchymal stem cell
vascular remodeling
nestin
vessel maturation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00169/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00169/full

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