Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis

Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis

Abstract Obesity, a global health challenge, is a major risk factor for multiple life-threatening diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify safe and tolerable therapeutics for obesity management. Herein, we show that treatment with artesunate, an art...

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Bibliographic Details
Main Authors: Xuanming Guo, Pallavi Asthana, Lixiang Zhai, Ka Wing Cheng, Susma Gurung, Jiangang Huang, Jiayan Wu, Yijing Zhang, Arun Kumar Mahato, Mart Saarma, Mart Ustav, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Pingyi Xu, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45452-3

Internet

https://doi.org/10.1038/s41467-024-45452-3

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