Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons

Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation of SFPQ are associated with the pathophysiology of...

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Bibliographic Details
Main Authors: Jocelyn Widagdo, Saumya Udagedara, Nishita Bhembre, Jing Zhi Anson Tan, Lara Neureiter, Jie Huang, Victor Anggono, Mihwa Lee
Format: Article
Language:English
Published: The Royal Society 2022-09-01
Series:Open Biology
Subjects:
amyotrophic lateral sclerosis
protein aggregation
DBHS proteins
glutamate receptors
RNA binding proteins
zinc
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.220187

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.220187

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