Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion

Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion

Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin-1 (PC1) and polycystin-2 (PC2). Among many pathog...

Full description

Bibliographic Details
Main Authors: Elizabeth J. Wilk, Timothy C. Howton, Jennifer L. Fisher, Vishal H. Oza, Ryan T. Brownlee, Kasi C. McPherson, Hannah L. Cleary, Bradley K. Yoder, James F. George, Michal Mrug, Brittany N. Lasseigne
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Molecular Medicine
Subjects:
Polycystic kidney disease
PKD
ADPKD
Drug repurposing
Signature reversion
LINCS
Online Access:https://doi.org/10.1186/s10020-023-00664-z

Internet

https://doi.org/10.1186/s10020-023-00664-z

Similar Items