Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo

Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo

Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very sho...

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Bibliographic Details
Main Authors: Valentina Maggisano, Marilena Celano, Rocco Malivindi, Ines Barone, Donato Cosco, Catia Mio, Chiara Mignogna, Salvatore Panza, Giuseppe Damante, Massimo Fresta, Sebastiano Andò, Diego Russo, Stefania Catalano, Stefania Bulotta
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cancers
Subjects:
triple negative breast cancer
targeted therapy
nanoparticles
bet inhibitors
jq1
Online Access:https://www.mdpi.com/2072-6694/12/1/91

Internet

https://www.mdpi.com/2072-6694/12/1/91

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