Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of <i>Wasabia japonica</i>
Wasabi (<i>Wasabia japonica</i> (Miq.) Matsum.) is a pungent spice commonly consumed with sushi and sashimi. From the roots of this plant, a new 2-butenolide derivative (<b>1</b>) and 17 previously reported compounds (<b>2</b>–<b>18</b>) were isolated...
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MDPI AG
2022-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/3/482 |
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| author | Jong Eel Park Tae Hyun Lee Song Lim Ham Lalita Subedi Seong Min Hong Sun Yeou Kim Sang Un Choi Chung Sub Kim Kang Ro Lee |
| author_facet | Jong Eel Park Tae Hyun Lee Song Lim Ham Lalita Subedi Seong Min Hong Sun Yeou Kim Sang Un Choi Chung Sub Kim Kang Ro Lee |
| author_sort | Jong Eel Park |
| collection | DOAJ |
| description | Wasabi (<i>Wasabia japonica</i> (Miq.) Matsum.) is a pungent spice commonly consumed with sushi and sashimi. From the roots of this plant, a new 2-butenolide derivative (<b>1</b>) and 17 previously reported compounds (<b>2</b>–<b>18</b>) were isolated and structurally characterized. Their chemical structures were characterized based on the conventional NMR (<sup>1</sup>H and <sup>13</sup>C, COSY, HSQC, and HMBC) and HRESIMS data analysis. All of these phytochemicals (<b>1</b>–<b>18</b>) were evaluated for their antiproliferative effects on the four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and MKN-1), for their inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 microglia cells, and for their nerve growth factor (NGF)-releasing effect from C6 glioma cells. Among the isolated compounds, compound <b>15</b> showed powerful antiproliferative activities against A549 and SK-MEL-2 cell lines with IC<sub>50</sub> values of 2.10 and 9.08 μM, respectively. Moreover, the new compound <b>1</b> exhibited moderate NO inhibition activity with IC<sub>50</sub> value of 45.3 μM. |
| first_indexed | 2024-03-09T20:11:51Z |
| format | Article |
| id | doaj.art-a2a466a8c98a4b27aed3c1c4ab973c61 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T20:11:51Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-a2a466a8c98a4b27aed3c1c4ab973c612023-11-24T00:12:58ZengMDPI AGAntioxidants2076-39212022-02-0111348210.3390/antiox11030482Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of <i>Wasabia japonica</i>Jong Eel Park0Tae Hyun Lee1Song Lim Ham2Lalita Subedi3Seong Min Hong4Sun Yeou Kim5Sang Un Choi6Chung Sub Kim7Kang Ro Lee8School of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaDepartment of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, KoreaGachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, KoreaGachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, KoreaGachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, KoreaKorea Research Institute of Chemical Technology, Daejeon 34114, KoreaSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, KoreaWasabi (<i>Wasabia japonica</i> (Miq.) Matsum.) is a pungent spice commonly consumed with sushi and sashimi. From the roots of this plant, a new 2-butenolide derivative (<b>1</b>) and 17 previously reported compounds (<b>2</b>–<b>18</b>) were isolated and structurally characterized. Their chemical structures were characterized based on the conventional NMR (<sup>1</sup>H and <sup>13</sup>C, COSY, HSQC, and HMBC) and HRESIMS data analysis. All of these phytochemicals (<b>1</b>–<b>18</b>) were evaluated for their antiproliferative effects on the four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and MKN-1), for their inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 microglia cells, and for their nerve growth factor (NGF)-releasing effect from C6 glioma cells. Among the isolated compounds, compound <b>15</b> showed powerful antiproliferative activities against A549 and SK-MEL-2 cell lines with IC<sub>50</sub> values of 2.10 and 9.08 μM, respectively. Moreover, the new compound <b>1</b> exhibited moderate NO inhibition activity with IC<sub>50</sub> value of 45.3 μM.https://www.mdpi.com/2076-3921/11/3/482<i>Wasabia japonica</i>Brassicaceae2-butenolideanticanceranti-neuroinflammation |
| spellingShingle | Jong Eel Park Tae Hyun Lee Song Lim Ham Lalita Subedi Seong Min Hong Sun Yeou Kim Sang Un Choi Chung Sub Kim Kang Ro Lee Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of <i>Wasabia japonica</i> Antioxidants <i>Wasabia japonica</i> Brassicaceae 2-butenolide anticancer anti-neuroinflammation |
| title | Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of <i>Wasabia japonica</i> |
| title_full | Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of <i>Wasabia japonica</i> |
| title_fullStr | Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of <i>Wasabia japonica</i> |
| title_full_unstemmed | Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of <i>Wasabia japonica</i> |
| title_short | Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of <i>Wasabia japonica</i> |
| title_sort | anticancer and anti neuroinflammatory constituents isolated from the roots of i wasabia japonica i |
| topic | <i>Wasabia japonica</i> Brassicaceae 2-butenolide anticancer anti-neuroinflammation |
| url | https://www.mdpi.com/2076-3921/11/3/482 |
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