Early life stress exacerbates behavioural and neuronal alterations in adolescent male mice lacking methyl-CpG binding protein 2 (Mecp2)

Early life stress exacerbates behavioural and neuronal alterations in adolescent male mice lacking methyl-CpG binding protein 2 (Mecp2)

The methyl-CpG binding protein 2 gene (MECP2) encodes an epigenetic transcriptional regulator implicated in neuronal plasticity. Loss-of-function mutations in this gene are the primary cause of Rett syndrome and, to a lesser degree, of other neurodevelopmental disorders. Recently, we demonstrated th...

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Bibliographic Details
Main Authors: Jose Vicente Torres-Pérez, Elena Martínez-Rodríguez, Anabel Forte, Carlos Blanco-Gómez, Oliver Stork, Enrique Lanuza, Mónica Santos, Carmen Agustín-Pavón
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
c-FOS
doublecortin
maternal separation
reelin
Rett sydrome
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.974692/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2022.974692/full

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