Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma

Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma

Bi-allelic inactivation of the VHL gene on chromosome 3p is the characteristic feature in most clear cell renal cell carcinomas (ccRCC). Frequent gene alterations were also identified in SETD2, BAP1 and PBRM1, all of which are situated on chromosome 3p and encode histone/chromatin regulators. The re...

Full description

Bibliographic Details
Main Authors: Svenja Bihr, Riuko Ohashi, Ariane L. Moore, Jan H. Rüschoff, Christian Beisel, Thomas Hermanns, Axel Mischo, Claudia Corrò, Jörg Beyer, Niko Beerenwinkel, Holger Moch, Peter Schraml
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S147655861830589X

Internet

http://www.sciencedirect.com/science/article/pii/S147655861830589X

Similar Items