Comparisons of Long-Term Survival and Safety of Haploidentical Hematopoietic Stem Cell Transplantation After CAR-T Cell Therapy or Chemotherapy in Pediatric Patients With First Relapse of B-Cell Acute Lymphoblastic Leukemia Based on MRD-Guided Treatment

Comparisons of Long-Term Survival and Safety of Haploidentical Hematopoietic Stem Cell Transplantation After CAR-T Cell Therapy or Chemotherapy in Pediatric Patients With First Relapse of B-Cell Acute Lymphoblastic Leukemia Based on MRD-Guided Treatment

Measurable residual disease (MRD) positivity before haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is an independent prognostic factor in determining outcomes in patients with B-cell acute lymphoblastic leukemia (ALL). In this study, we conducted a parallel comparison of the eff...

Full description

Bibliographic Details
Main Authors: Guanhua Hu, Yifei Cheng, Yingxi Zuo, Yingjun Chang, Pan Suo, Yueping Jia, Aidong Lu, Yu Wang, Shunchang Jiao, Longji Zhang, Yuqian Sun, Chenhua Yan, Lanping Xu, Xiaohui Zhang, Kaiyan Liu, Leping Zhang, Xiaojun Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
CAR-T therapy
B-cell acute lymphoblastic leukemia
pediatric
haploidentical hematopoietic stem cell transplantation
measurable residual disease (MRD)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.915590/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.915590/full

Similar Items