Intracerebroventricular administration of the (1→6)-β-d-glucan (lasiodiplodan) in male rats prevents d-penicillamine-induced behavioral alterations and lipoperoxidation in the cortex

Intracerebroventricular administration of the (1→6)-β-d-glucan (lasiodiplodan) in male rats prevents d-penicillamine-induced behavioral alterations and lipoperoxidation in the cortex

Context: Lasiodiplodan, an exocellular (1→6)-β-d-glucan of molecular weight >1.4 × 106 Da produced by MMPI strain of Lasiodiplodia theobromae (Pat.) Griffon & Maubl. (Brotyosphaeriaceae) is known to exhibit anti-proliferative activity on breast cancer cells (MCF-7), anticoagulant activity whe...

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Bibliographic Details
Main Authors: Carlos Ricardo Maneck Malfatti, Fabio Seidel dos Santos, Jéssica Wouk, Luiz Augusto da Silva, Renan Garcia Michel, André Luiz Snak, Tiago Czervinski, Mário A. Alves da Cunha, Aneli M. Barbosa, Robert F. H. Dekker
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Pharmaceutical Biology
Subjects:
convulsions
free radicals
gabaergic system
neurotoxicity
Online Access:http://dx.doi.org/10.1080/13880209.2017.1299767

Internet

http://dx.doi.org/10.1080/13880209.2017.1299767

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