Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase

Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase

Summary: Bacteriophage T3 encodes a SAMase that, through cleavage of S-adenosyl methionine (SAM), circumvents the SAM-dependent type I restriction-modification (R-M) defense. We show that SAMase also allows T3 to evade the BREX defense. Although SAM depletion weakly affects BREX methylation, it comp...

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Bibliographic Details
Main Authors: Aleksandr Andriianov, Silvia Trigüis, Alena Drobiazko, Nicolas Sierro, Nikolai V. Ivanov, Maria Selmer, Konstantin Severinov, Artem Isaev
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300983X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472300983X

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