Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations

Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations

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miR-486 is a myogenic microRNA, and its reduced skeletal muscle expression is observed in muscular dystrophy. Transgenic overexpression of miR-486 using muscle creatine kinase promoter (MCK-miR-486) partially rescues muscular dystrophy phenotype. We had previously demonstrated reduced circulating an...

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Bibliographic Details
Main Authors: Ruizhong Wang, Brijesh Kumar, Emma H. Doud, Amber L. Mosley, Matthew S. Alexander, Louis M. Kunkel, Harikrishna Nakshatri
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
DMD:non-coding RNAs
breast cancer
functional limitations
miR-486
skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122000580

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http://www.sciencedirect.com/science/article/pii/S2162253122000580

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