TRIM21-regulated Annexin A2 plasma membrane trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated autophagy

TRIM21-regulated Annexin A2 plasma membrane trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated autophagy

Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, which is characterized by dysfunctional autophagy and poor differentiation. Our recent studies have suggested that the tripartite motif containing-21 (TRIM21) plays a crucial role in regulating OS...

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Bibliographic Details
Main Authors: Huan-Tian Zhang, Qingzhong Zeng, Baomeng Wu, Junlei Lu, Kui-Leung Tong, Jiebin Lin, Qiu-Yu Liu, Lipei Xu, Jie Yang, Xiaohui Liu, Wanting Liu, Yun-Fang Zhang, Qionghua Lian, Langxia Liu, Xuejuan Gao
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03364-2

Internet

https://doi.org/10.1038/s41419-020-03364-2

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