Chromatin accessibility dynamics in colorectal cancer liver metastasis: Uncovering the liver tropism at single cell resolution

Tumor metastasis causes over 90% of cancer related death and no currently available therapies target it. However, there is limited understanding regarding the epigenetic regulation of genes during this complex process. Here by integrating single-cell ATAC-seq (scATAC-seq), single-cell RNA-seq (scRNA...

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Bibliographic Details
Main Authors: Shasha Li, Ming Yang, Shuaishuai Teng, Kequan Lin, Yumei Wang, Yanmei Zhang, Wei Guo, Dong Wang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Pharmacological Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823002529