Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel.

Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel.

Increasing evidence supports a critical role of T cells in neurodegeneration associated with acute and subacute brain inflammatory disorders. Granzyme B (GrB), released by activated T cells, is a cytotoxic proteinase which may induce perforin-independent neurotoxicity. Here, we studied the mechanism...

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Bibliographic Details
Main Authors: Tongguang Wang, Myoung-Hwa Lee, Elliot Choi, Carlos A Pardo-Villamizar, Sung Bin Lee, In Hong Yang, Peter A Calabresi, Avindra Nath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3430617?pdf=render

Internet

http://europepmc.org/articles/PMC3430617?pdf=render

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