Synthesis of a Non-Symmetrical Disorazole C<sub>1</sub>-Analogue and Its Biological Activity

Synthesis of a Non-Symmetrical Disorazole C<sub>1</sub>-Analogue and Its Biological Activity

The synthesis of a novel disorazole C<sub>1</sub> analogue is described, and its biological activity as a cytotoxic compound is reported. Based on our convergent and flexible route to the disorazole core, we wish to report a robust strategy to synthesize a non-symmetrical disorazole in w...

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Bibliographic Details
Main Authors: Luca Lizzadro, Oliver Spieß, Silke Reinecke, Marc Stadler, Dieter Schinzer
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
non-symmetrical disorazole
convergent synthesis
biological activity
SAR (structure-activity-relationship)
Online Access:https://www.mdpi.com/1420-3049/29/5/1123

Internet

https://www.mdpi.com/1420-3049/29/5/1123

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