Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies

Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies

The entry of SARS-CoV-2 into host cells is mediated by the interaction between the spike receptor-binding domain (RBD) and host angiotensin-converting enzyme 2 (ACE2). Certain human antibodies, which target the spike N-terminal domain (NTD) at a distant epitope from the host cell binding surface, ha...

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Bibliographic Details
Main Authors: Tina Lusiany, Tohru Terada, Jun-ichi Kishikawa, Mika Hirose, David Virya Chen, Fuminori Sugihara, Hendra Saputra Ismanto, Floris J. van Eerden, Songling Li, Takayuki Kato, Hisashi Arase, Matsuura Yoshiharu, Masato Okada, Daron M. Standley
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Viruses
Subjects:
infection enhancing antibody
cross-linking
SARS-CoV-2
spike protein
molecular dynamics
cryo-EM
Online Access:https://www.mdpi.com/1999-4915/15/12/2421

Internet

https://www.mdpi.com/1999-4915/15/12/2421

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