SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation

SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation

Abstract Reissner’s fiber (RF) is an extracellular polymer comprising the large monomeric protein SCO-spondin (SSPO) secreted by the subcommissural organ (SCO) that extends through cerebrospinal fluid (CSF)-filled ventricles into the central canal of the spinal cord. In zebrafish, RF and CSF-contact...

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Bibliographic Details
Main Authors: Huixin Xu, Guillaume P. Dugué, Yasmine Cantaut-Belarif, François-Xavier Lejeune, Suhasini Gupta, Claire Wyart, Maria K. Lehtinen
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Fluids and Barriers of the CNS
Subjects:
SCO-spondin/SSPO
Subcommissural organ (SCO)
Reissner’s fiber
Cerebrospinal fluid
Spinal cord
Ventricular volume
Online Access:https://doi.org/10.1186/s12987-023-00491-8

Internet

https://doi.org/10.1186/s12987-023-00491-8

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