Soft substrate maintains proliferative and adipogenic differentiation potential of human mesenchymal stem cells on long-term expansion by delaying senescence

Soft substrate maintains proliferative and adipogenic differentiation potential of human mesenchymal stem cells on long-term expansion by delaying senescence

Human mesenchymal stem cells (hMSCs), during in vitro expansion, gradually lose their distinct spindle morphology, self-renewal ability, multi-lineage differentiation potential and enter replicative senescence. This loss of cellular function is a major roadblock for clinical applications which deman...

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Bibliographic Details
Main Authors: Sanjay Kumar Kureel, Pankaj Mogha, Akshada Khadpekar, Vardhman Kumar, Rohit Joshi, Siddhartha Das, Jayesh Bellare, Abhijit Majumder
Format: Article
Language:English
Published: The Company of Biologists 2019-04-01
Series:Biology Open
Subjects:
Cell mechanics
Mesenchymal stem cells
Senescence
Stemness
Substrate rigidity
Online Access:http://bio.biologists.org/content/8/4/bio039453

Internet

http://bio.biologists.org/content/8/4/bio039453

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